![]() ![]() 78. Freitas JC, Presgrave OA, Fingola FF, Menezes MA, Paumgartten FJ. Effect of beta-myrcene on pentobarbital sleeping time. Furthermore, research on mouse models has demonstrated the potential of this terpene to treat ischemic stroke, due to its neuro and cardiac protective effects. Analyses of essential oils high in myrcene content have also indicated the possible antioxidant and anti-ulcer properties of this terpene. Various studies on animal models have shown some promising applications for this terpene, including sedation, muscle relaxation, anti-inflammation, and overall pain relief. Often used as an additive in food manufacturing, myrcene can also be found naturally in mangos, lemongrass, and bay leaves. 2022.Īs one of the most common terpenes present in the cannabis plant, myrcene can be found in cultivars worldwide. “Physiological and Psychological Effects of Olfactory Stimulation with D-Limonene.” Advances in Horticultural Science, vol. ![]() Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown. do Vale TG, Furtado EC, Santos JG Jr, Viana GS. Effect of d-limonene and its derivatives on breast cancer in human trials: a scoping review and narrative synthesis. Chebet JJ, Ehiri JE, McClelland DJ, Taren D, Hakim IA. “Chemoprevention and Therapy of Cancer by d-Limonene.” Critical Reviews™ in Oncogenesis 5,1–22, DOI:10.1615/CritRevOncog.v5.i1.10 (1994). Patel, M., Narke, D., Kurade, M. et al. Limonene-induced activation of A2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma. Purinergic Signalling 16, 415–426 (2020). Ryoji Hirota, Hiroyuki Nakamura, Sabah Asif Bhatti, Nlandu Roger Ngatu, Basilua Andre Muzembo, Narongpon Dumavibhat, Masamitsu Eitoku, Masayoshi Sawamura & Narufumi Suganuma (2012)“Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinaetreated mice.”Inhalation Toxicology 24:6, 373-381, DOI:10.3109/08958378.2012.675528 (2012) Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress. Behav Neurol. Lorigooini Z, Boroujeni SN, Sayyadi-Shahraki M, Rahimi-Madiseh M, Bijad E, Amini-Khoei H. Limonene has anti-anxiety activity via adenosine A2A receptor-mediated regulation of dopaminergic and GABAergic neuronal function in the striatum. Song Y, Seo S, Lamichhane S, Seo J, Hong JT, Cha HJ, Yun J. “Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice.” Behavioural Brain Research 172, 240–249, DOI:10.1016/j.bbr.2006.05.006 (2006) When combined, these properties may implicate limonene as being helpful in the treatment of those suffering from related symptoms due to Qualifying Conditions. It has also been identified as having antioxidant and anti-cancer properties in human trials and has been identified as a potential muscle relaxant and relaxation aid. ![]() It has been identified in peer-reviewed research as inducing anti-stress, anti-anxiety, anti-depressant, and anti-inflammatory (in the airways), effects in mouse models. ![]() It is commonly used in foods, beverages, fragrances, cleaners, and cosmetics due to its pungent sweet citrusy aroma. Limonene is a terpene commonly found in the peels of citrus fruits like lemons, limes, and oranges, as well as in cannabis flowers, spruce trees, and other plants. ![]()
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